Have you been feeling unusually tired or sluggish lately? Trouble sleeping? A lack of sexual desire?”

“At our clinic, we offer specialized consultations for male menopause (Late-Onset Hypogonadism, or LOH syndrome).

Our clinics are located in Yokohama and Ueno, and we offer the same services and pricing at both sites.

• 1. What is Male Menopause (Late-Onset Hypogonadism, LOH)?
• 2. Diagnostic and Treatment Procedure
• 3. Costs (All Prices Tax Included)

1. What is Male Menopause (Late-Onset Hypogonadism, LOH)?

Male menopause (Late-Onset Hypogonadism, or LOH) is a condition in which declining testosterone levels with age lead to symptoms such as reduced sexual function and mental or neurological issues.

Although awareness of this condition is gradually increasing in Japan, many men who require treatment are still not receiving the care they need.

At our clinic, you can consult with a certified testosterone therapy specialist to discuss appropriate hormone treatment options and long-term care plans. Please feel free to reach out—we’re here to support you.

Physical symptoms

Common symptoms may include decreased muscle strength, persistent fatigue, reduced stamina, hot flashes, excessive sweating, headaches, dizziness, tinnitus, low libido, and erectile dysfunction.

Mental symptoms

Psychological symptoms may include loss of motivation or interest, irritability, increased anxiety, depression, insomnia, and difficulty with concentration and memory.

If you are experiencing two or more of these symptoms, you might be dealing with male menopause (Late-Onset Hypogonadism).

Male menopause, or Late-Onset Hypogonadism, differs from female menopause in that it has no defined onset period. The symptoms may continue indefinitely once hormonal decline begins, unless properly managed.

2. Diagnostic and Treatment Procedure

Medical consultation and counseling

Patients who see a doctor and are suspected of having symptoms of male menopause (LOH), or those who wish to undergo testing, can receive detailed examinations.

Additionally, consultations for androgenetic alopecia (AGA), erectile dysfunction (ED), and sexually transmitted infections (STIs) are also available.

Examination

We check testosterone levels through blood tests, along with assessments of liver and kidney function, as well as screening for lifestyle-related diseases.

We also take into account the symptoms you personally experience to make a comprehensive judgment on whether treatment is appropriate, so please rest assured.

Treatment

For male menopause (LOH), short-acting testosterone injections are commonly used. However, for busy patients, regular visits can be difficult, and prolonged treatment may cause fluctuations in blood hormone levels after administration, increasing the risk of side effects.

At our clinic, we offer long-acting testosterone injections (commonly known as Nebido), as well as oral medications (usually 1 to 2 tablets per day) and topical gels.

Regular check-ups / Consultations for AGA, ED, and Premature Ejaculation

In testosterone replacement therapy, testosterone levels are regularly monitored, and patients continue treatment while regularly consulting with their doctor to assess symptom changes.

We also provide consultations and treatments for androgenetic alopecia (AGA) and erectile dysfunction (ED), including medication therapy for ED.

3. Costs (All Prices Tax Included)

Examination Fees (At Initial Visit)

Initial blood test set (including hormone tests)	¥10,000
Initial STI test set (simultaneous testing of gonorrhea and chlamydia at 3 sites, HIV, syphilis, hepatitis B)	¥10,000 (regular price: ¥20,000)
Hormone test only (testosterone, free testosterone)	¥3,000
PSA test (prostate cancer screening, optional)	¥2,000

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Examination Fees (After Starting Hormone Therapy)

blood test	price
Hormone test only (testosterone, free testosterone)	¥3,000
Lifestyle-related disease tests (liver function, kidney function, lipids, diabetes, uric acid, optional)	¥5,000
D-dimer test (for thrombosis evaluation, optional)	¥1,500

Treatment Fees (Hormone Therapy)

Nebido generic oral medication (Sernos capsules)

1 box (30 tablets)	¥5,000
3 boxes (90 tablets)	¥14,000
6 boxes (180 tablets)	¥27,000

Nebido generic injection (Sernos Depot)

Per injection

¥16,500

Nebido generic topical medication (Sernos gel)

per month

Approximately ¥6,000 to ¥13,000

1% testosterone topical agent

Glomin

¥4,100

5% testosterone topical agent

1UP Formula
Prescription fee	¥2,200
Medication cost	¥12,000

Short-acting Testosterone Injections

Testoviron 100mg	¥2,500
Testoviron 250mg	¥3,500